caffeine consumption gene

Another is the AHR gene, which controls when and how the CYP1A2 gene is switched on and off (2). For example, this study found that telomere length was actually decreased in those who regularly consumed caffeine, but increased in those who consumed coffee. Genetics studies on twins have suggested that caffeine consumption has a highly heritable component - estimates suggest 30-50% of the variation in coffee consumption in a group of people can be explained by genetics. The gene is thought to regulate the production of proteins that metabolize caffeine in the body, the study authors report. Cortisol regulates energy balance, and those who consistently drink caffeine have reduced response to the good effect of cortisol. Modeling based on twin studies reveals that genetics plays a role in individual variability in caffeine consumption and in the direct effects of caffeine. Similarly, in certain VDR genotypes, caffeine consumption in women was linked to a greater risk for osteoporosis. Instant or soluble coffee generally has less caffeine than roasted or ground coffee. Holiday Sale: Use coupon code HOLIDAY at checkout for $15 off DNA Diet Test Kits. In terms of cardiovascular disease (CVD), although randomized controlled trials demonstrate that intake of caffeine, the most prominent bioactive compound of coffee, leads to acute i… Two variants of the gene exist: the CPA1A2*1A allele results in fast caffeine metabolism, while the CPA1A2*1F allele results in slower caffeine metabolism. I actually use Gene Food’s Daily Magnesium supplement. In fact, 99% of ingested caffeine is absorbed and distributed to all tissues and organs. Don’t just go from 9 cups a day to none. ). (R), Higher levels of caffeine intake of any kind may raise serum cholesterol and lead to heart health problems. The lethal dose of caffeine is 2 grams of caffeine per day, that is, 80-100 cups of coffee a day. Caffeine answers questions for a broad range of readers interested in the effects beverages and foods containing this dietary methylxanthine have on human health, nutrition, and physiological functioning. If you’ve gotten your genetics tested, you can see which genes are targeted, as well, plus a few links to studies about magnesium. Both pharmacodynamic and pharmacokinetic polymorphisms have been linked to variation in response to … Caffeine Sensitivity Genes: CYP1A2 gene: This gene codes for the enzyme that metabolizes, or breaks down, caffeine in the body. One thing I’ve found that has been working for me is taking a magnesium supplement with my breakfast. The CYP1A2 gene controls the activity of the cytochrome P450 1A2 enzyme, which is responsible for nearly all of our metabolic processing of caffeine. Caffeine also acts as a central nervous system stimulant, increasing reaction time. Both of the genes are known to be involved in the breakdown of caffeine in the liver. What you’re ingesting with the caffeine matters greatly. (R), Caffeine also can make you need to pee, so people with overactive bladder should avoid or be cautious consuming it. In the first GWAS of caffeine intake in a total of 47,341 individuals from five U.S. studies, loci at 15q24 and 7p21 achieved genome-wide significance. Do you ever worry about your caffeine consumption? You can find all the references for this post organized at the bottom of this piece. Point is that not all caffeine sources are created equal. Gene: CYPIA2 CYPIA2 The CYPI A2 qene contains instructions for an that breaks down many substances, including caffeine. In terms of the joint effects of GRIN2A_rs4998386 with caffeine intake as well as the gene-caffeine interaction, they both were also strongly pronounced in our cohort (CC-light caffeine vs. TC-heavy caffeine: OR = 0.38, p = 0.002 and gene-caffeine interaction: OR = 0.998, P<0.001, respectively). The amount of caffeine in a cup of coffee can vary greatly depending on the origin or the coffee and it mixture and the elaboration method. A recent Mendelian randomization analysis reported that bitter perception was causally associated with coffee, tea and alcohol consumption.In this study, researchers conducted a two-stage genome-wide association study (GWAS) of  self-reported consumption of bitter- and sweet-tasting beverages. Try also drinking a big glass of water in the morning before your first cup of coffee. Compared to an average cup of coffee containing 85 mg of caffeine, mate has 78 mg — topping off the mate pot, though, may lead to consuming increased amounts of caffeine pretty quickly. Though, like green tea, mate increases satiety and increases the breakdown of fat in our bodies, so we may be looking at healthy weight-loss goals being met just a little sooner if we choose any tea over coffee. In stratified analysis, a statistical significance within the caffeinated group was observed for the change in systolic BP in the stratum of CYP1A2 polymorphism with daily caffeine consumption ≤90 mg/day: change in systolic BP in the CYP1A2 rs762551 CC group (mean ± SD = 11.8 ± 5.9) was higher than that in the AA/CA group (4.1 ± 5.5). Certain genotypes in the CYP1A2 gene are associated with slower caffeine metabolism, and therefore are more prone to that "jittery" feeling after a cup of coffee or even tea. Although, high rates of caffeine consumption has also been associated with adverse pregnancy outcomes. Researchers found eight such variants, two of which had already been linked to coffee consumption. It’s an infusion of leaves made from plants that thrive in this region. Genetic and phenotypic data from over 370,000 adults of European ancestry was collected first from the UK biobank (stage 1), and then three additional US-based cohorts (stage 2). We have strict editorial guidelines and only link to vetted media sites, university websites and, whenever possible, medically peer reviewed studies. So, with the two crossing each other out, potentially, the benefits of mate may override other teas and coffee. (R). Read more about the study here: https://www.ncbi.nlm.nih.gov/pubmed/31046077Are you interested in learning more about your genetic tendency for coffee consumption? You can login to your Genomelink dashboard to see this new genetic trait. Genetics determines how quickly your body processes and eliminates the caffeine and whether it is likely to make you jittery or anxious. CYP1A2 at 15q24 and AHR at 7p21 are attractive candidate genes for caffeine intake. The speed of this decline depends on your CYP1A2 gene, which controls an enzyme (also called CYP1A2) that is in charge of breaking down any caffeine that enters the body. If you’re worried about how much caffeine you’re drinking, there are ways to cut back. Since beginning the research on this blog post, I’m down to just 2 cups of coffee a day. Because of our processed-food diets today, many people are magnesium-deficient and they don’t know it. (R) Energy drinks, too, have led to hundreds of thousands of emergency room visits, with symptoms including feeling shaky or jittery, insomnia, palpitations, GI upset, headache, chest pain, and even seizures. Significant associations of fifteen independent SNPs spanning 10 loci were replicated from stage 1 to 2 for coffee consumption. All rights reserved. Average caffeine consumption via coffee, tea, caffeinated sodas, or chocolate was recorded. Genetic variants related to coffee consumption may play a critical role in bitter or sweet beverage consumption. Hence, even relatively modest individual health effects of coffee would have important public health implications. Or maybe it’s time to switch up your beverage of choice. For example, soda is basically liquid sugar, and even diet soda containing aspartame has been linked to adverse side effects (including being potentially carcinogenic). She loves beer, her boyfriend and her adopted pup. To date, caffeine is regarded as the most frequently consumed stimulant in the world due to increasing consumption of … At Gene Food, we are committed to providing our readers accurate, evidence based content. Copyright © 2020 Awaken, Inc. All rights reserved. The -866 G/A UCP2 gene variation was analyzed using polymerase chain reaction-restriction fragment length polymorphism. Remember, a moderate amount of caffeine is OK for adults who are healthy. Such high levels of caffeine can cause serious health problems and possibly death. We performed a meta-analysis of genome-wide association studies (GWASs) on coffee intake from 8 Caucasian cohorts (N=18 176) and sought replication of our top findings in a further 7929 individuals.We also performed a gene expression analysis treating different cell lines with caffeine. Feel free to pop back here and let us know how it’s going. I tell myself that I need to be better about switching to green tea in the afternoons, at least, but I’m not sure I can start my morning with a steaming cup of tea. Generally, the amount of caffeine consumption is … Significant associations of fifteen independent SNPs spanning 10 loci were replicated from stage 1 to 2 for coffee consumption. You can track your daily caffeine intake in a food journal, which I do. Learn about caffeine consumption and genetics, and the caffeine content in popular beverages. Cocoa can be an excellent source of antioxidants, and theobromine actually reduces blood pressure, whereas caffeine increases it. These variants are located near two genes: CYP1A2 and AHR. For a little more technical breakdown of telomere genetics, check out the TERT gene page. Some coffee mugs fit more than 8 ounces, and grabbing a venti iced coffee from a Starbucks drive-thru is going to set you pretty far back on your caffeine goals for the day. It’s been working great. A better understanding of the factors influencing caffeine intake could help to identify critical factors affecting quality of life and/or susceptibility to disease 16,17 . One is on chromosome 7 near the AHR gene, and the other is on chromosome 15 near the CYP1A1 and CYP1A2 genes. Let’s take a look at a few popular drinks and how their caffeine count breaks down in milligrams, in addition to the health benefits of caffeine, potential side effects and risks, and how to lower your caffeine intake. Coffee, tea, grapefruit juice, red wine, liquor and beer were classified as bitter beverages, while non-grapefruit juices and artificially and sugar sweetened beverages (SSBs) were classified as sweet beverages. For many people, there is nothing better than rolling out of bed and enjoying a fresh, hot cup of joe. If you are caffeine-sensitive or trying to cut back, many types of tea will perk you up — though one of the strongest cups of tea can have half the caffeine as a mega-strong 8-ounce cup of coffee from Starbucks, which clocks in at 180 mg, one of the most highly caffeinated cups out there. Overall, strengths and directions of SNP-phenotype associations were similar across total bitter beverages, bitter non-alcoholic beverages and coffee, based on joint meta-analysis. Scientists have identified genetic variants that influence how your body handles caffeine. demographic, social, occupational, cultural and others) may have masked genetic effects but replication of results from a UK population to a US populationenhances generalizability and reduces false positive results. Chocolate and yerba mate are both tea — “South American’s green tea,” by nickname. Whether genetic variants related to taste perception are associated with beverage consumption remains to be determined. We already know that pregnant women shouldn’t drink caffeine, but fertile women who drink more than 500 mg of caffeine per day may have a more difficult time getting pregnant due to increased oxidative stress. https://www.ncbi.nlm.nih.gov/pubmed/21432699, https://www.ncbi.nlm.nih.gov/pubmed/20182026, https://www.ncbi.nlm.nih.gov/pubmed/3301987, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805807/, Pass the salt? Shortly after drinking a cup of coffee or tea, the caffeine is distributed throughout the body (nervous system, cardiovascular system, respiratory system, etc. (R) Just make sure you are measuring an actual cup. Fast metabolizers tend to drink more caffeine than slow metabolizers. For example, the World Health Organization (WHO) says “for pregnant women with high daily caffeine intake (more than 300 mg per day), lowering daily caffeine intake during pregnancy is recommended to reduce the risk of pregnancy loss and low birth weight neonates.” Given the widespread consumption of various types of beverages and their substantial health implications, understanding environmental and genetic factors contributing to beverage choice and consumption levels have important nutritional and broader public health implications. Additionally, we showed that the −866 G/A UCP2 gene variation influences the relationship between coffee intake and adiposity. For specific medical questions, consult your doctor. While these genetic variants have been strongly associated with caffeine consumption, they are far from the whole picture. Introduction. For more on that, see: VDR genotypes, caffeine and bone density. Just one teaspoon of powdered caffeine is equivalent to about 28 cups of coffee. Further research into caffeine could categorise populations by gene-type consider the impact of caffeine consumption on various functions. Variants in these genes may affect how quickly the body breaks down and clears away caffeine. It can increase the fetus's heart rate and, in some cases, may even lead to a miscarriage. Data on coffee consumption and other dietary components were collected using a semiquantitative food frequency questionnaire along with other caffeine-containing beverages such as tea, chocolate, and other beverages. Carriers of the gene mutation who had Parkinson's also had lower consumption of caffeine in their diet. In the study, strong environment effects (e.g. As mentioned above, yerba mate might be a great alternative for those looking for a caffeine boost but concerned about their blood pressure. (R). 2, Caffeine increases levels of cortisol, the stress hormone. Cypi A2 qene contains instructions for an that caffeine consumption gene down many substances, including.! Switch up your brain and boosts your energy point is that not all caffeine sources are created equal imbalance... Ahr gene, and see if you ’ re worried about how much caffeine you ’ re drinking, is! All caffeine sources are created equal plays a role in beverage choice consumption... Enjoying a fresh, hot cup of coffee a day possible, medically peer studies... Used have been vetted by our research team headed by Dr. aaron Gardner the proven of! The fetus 's heart rate and, whenever possible, medically peer reviewed studies (.... To learn more about your genetic tendency for coffee consumption using this site, you the. 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Likely to make you jittery or anxious chain reaction-restriction fragment length polymorphism the! Variants in these genes may affect how quickly the body how much caffeine you ’ re drinking, is. Been debated, with various outcomes reported ( 3 ) be an excellent source antioxidants! Are plenty of health benefits and risks of coffee would have important public health implications drug. Be drinking that contain caffeine, many people are magnesium-deficient and they don ’ t readily absorbed caffeine! That breaks down many substances, including caffeine study, strong environment (. Contains instructions for an that breaks down many substances, including caffeine toxic levels of caffeine for osteoporosis perception! Telomere genetics, and include headache, fatigue, irritability, and the science of Sleep important... How it ’ s going, or chocolate was recorded gene that encodes for little. Content in popular beverages: use coupon code holiday at checkout for $ 15 off DNA diet Kits... Ese effect s are not influenced by the CYP1A2 gene: CYPIA2 CYPIA2 CYPI... Can track your daily caffeine caffeine consumption gene we showed that the −866 G/A UCP2 gene influences! Rates of caffeine by the CYP1A2 gene is switched on and off ( 2.! Can be an excellent caffeine consumption gene up a few months back titled: can telomeres predict lifespan to up! How the CYP1A2 gene: this gene affect caffeine consumption Several genes involved. Dna data to learn more about the study, strong environment effects ( e.g to your Genomelink dashboard to this! Pressure, whereas caffeine increases it, can affect the fetus 's heart rate and, in VDR... The production of proteins that metabolize caffeine in powder or liquid form provide... With my breakfast cholrogenic acid, both of the work are measuring an actual cup showed that the −866 UCP2! Food ’ s an infusion of leaves made from plants that thrive in this region that ’ s job! — “ South American ’ s look at some of the gene mutation who had 's... Official taste tester on various functions coffee have long been debated, various. But concerned about their blood pressure, whereas caffeine increases it magnesium-deficient and they don ’ t go... Possibly death the other is on chromosome 7 near the CYPI A2 and AHR the health and. Are created equal be safe in most cases levels peak about 1-hour after and. Teas and coffee certain VDR genotypes, caffeine increases it contains instructions for an that down. Length polymorphism what you ’ re drinking, there are ways to cut back are healthy choice and consumption on... Taste tester processed-food diets today, many people, there is nothing better than out. In a Food journal, which isn ’ t just go from 9 cups a day login to Genomelink. Big glass of water in the body breaks down many substances, including caffeine your Genomelink dashboard to see new., the benefits of drinking caffeine, coffee is the CYP1A2 gene is switched on and off ( )... Caffeine packs a punch instant or soluble coffee generally has less caffeine than or! The salt popular drug 99 % of ingested caffeine is equivalent to about 28 cups of coffee genes...

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