una irritaci=F3n cut=E1nea y respiratoria grave.
de
Kannan K, Senthilkumar K, Loganathan BG, Takahashi S, Odell DK, =
determined by the duplicate-portion method were 4.7 + 7.0 =
synergistic effects on reproduction, resulting in reduced spawning
*** P < 0.001). laboratoire. AAAAAAABAAIRAzMhkdESNDFBoSIEcRMQQFFhgbHBMkJyoiMgUoKykkOzBVBg0vJj0xQSAAECBAUE
Hotline
column ranges from a few days to weeks. and 30% lower, respectively, at an effector to target cell ratio of
sources
Information on
the framework of the legislation of that country. 1998. Fent K, Hunn J (1991) Phenyltins in water, sediment, and biota of
suggests that this might not be the case.
compound-related effect. administered separately. ------=_NextPart_000_0000_01CA5BD8.85A81850--, 2. 4. A reanalysis of the slides
weanling or aged (1-year-old) rats to TBTO for 4.5 months. average concentration in four samples was 84 ng/g wet weight (range
"https://ssl." Tanabe S, Prudente M, Mizuno T, Hasegawa J, Miyazaki N (1998) =
le
document. day) weight per day)
NXpPL5wT79+/fv379+/fv379+/fv379+/fv37xOoCsBBWgYR8aE0ZNcvgEagYlxXg6bqKghVq+JL
US EPA (1997): Toxicological review on tributyltin =
var gaJsHost =3D (("https:" =3D=3D document.location.protocol) ? more important than uptake directly from water. in short-term studies. study, the authors reported no information on particle size or the
qBN7sRsrnhgLYR+LrSG7YyMrrSVLsieLeynLEw3bVS2rVS9rdSursjNbsTX/i2Q3ezM526tctrMq
male Fischer rats or pre-weanling (3-24 days old) rats were dosed by
montre qu'il n'est pas non plus g=E9notoxique. in
compounds
transferred
al.,
lOGAPCrwKeFSaZEaoxz4S0UbI3nXuxYytpkcOuI0YIQdU2QWAkwBZtAbuzMujF9xuTcm5Nybk3Ju
Report to Swedish National =
tributyltin adsorbs readily onto particles. 10.1. 5. sur la S=E9curit=E9 chimique (IPCS, 1996) est =E9galement reproduite =
Neurotoxicity
Schroeder RE (1990) A two-generation reproduction study in rats =
the incidence of neoplastic lesions. 0.5 Verdier et al., 1991
/oMJwMZTRsMZRqveWI65R5bK+yUadtx6uxwhZD+T6VU7IAAAAAAAAAAADdKN49HAKD5nogAAAAAA
According to the
In this case, =
persist in sediment for several years. =20
health hazards
PGypK7B4rb/4Kz+9hNfAWKMPyi/wol4Uy76Fu6n6d0nR8s+ne2GbjF0f8y93bdfpGtk5+tIInbEr
Su aprobaci=F3n tuvo lugar como =
6.1. immunity
- to provide guidance to those responsible for the preparation of
frequency, number of eggs, and proportion of fertile eggs (Oshima et
For target snail adults, the 24-h LC50 was 30-400 =
World Health Organization (WHO), the International Labour =
documento aparece tambi=E9n la informaci=F3n adicional obtenida =
brevispina) was
chemical toxicology, 30:715-718. pituitary tumoursb =
the principal study. international review. these maximum concentrations of tributyltin should not be taken as
algunos
Marine environmental =
contamination and
FYI-OTS-0687-0550 Sequence A). it meets the specified criteria for CICADs. histopathological changes) observed at the highest dose, the LOAEL =
DAwMDAwQDA4PEA8ODBMTFBQTExwbGxscHx8fHx8fHx8fHwEHBwcNDA0YEBAYGhURFRofHx8fHx8f
Littorina littorea, and Nassarius reticulatus =
O-Sn(CH2CH2CH2CH3)3. Protection,
showed that these effects were absent or occurred at a higher dose
species (including benthic invertebrate and fish larvae), and
The NOAEL is 0.025 mg/kg body weight per day (Krajnc et al.,
documented
Unless otherwise stated, CICADs are based on a search of
REFERENCES
micronuclei (IPCS, 1990). mutagenic in the rec assay in Bacillus subtilis, did not =
AsAa6GY2WFS2GPKPi28P82f/2gAIAQEDAT8h80ePIcEQ/AkrCPc/slIF9oaZEWWQtUhegf7mh+t7
severe adverse effects. HUMANS, 8.4.2. WlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FWyNgAHM7YLBvVD6n4
1992
Rat 6 weeks Reduced thymus 8 =
APPENDIX 2 -- CICAD PEER REVIEW
The second stage involves international peer review by =
toxicology, 58:489-496. XXVFmNyF3DT7il6k+iAaLXnNzABRA3ajRykvpbmvTjNLVM3je1mLDTlzGoFn8SyBZpoYxVXDJKt/
A study =
tributyl=E9tain. CEFIC (1994) Use of triorganotin compounds in anti-fouling =
ineffective. Organ weights =
tributyl=E9tain
is
single
It has been suggested that other prosobranchs =
pH, it is barely evident under normal environmental conditions. ng/g in muscle of marine mammals have been reported (Iwata et al.,
phenolic compounds. States Environmental Protection Agency, US EPA) =E0 partir d'un =
are also more sensitive than adults, the 96-h LC50s being =
4-h IC50 for primary production of 3 =B5g/litre was =
protein binding in liver to be the major mechanism of =
conduct a route-to-route extrapolation for extra-respiratory =
body (mg/kg body
Based on the
ENVIRONMENTAL =
Based on its review, EPA is now releasing its Reregistration Eligibility Decision (RED) and risk management decision for tributyltin. =
En estos ex=E1menes se analizaron =
mg/kg sediment was determined for Amphioxus (IPCS, 1990). Mouse gestation days Haematology - =
1XfQfuYtZluBmREoGG30MSjgZP01Zh1j97nXGnueQegcgBwGJ96GBirYoID4VYcXdhkuOCF8xE3n
ptY1FmnW4SOhxTtuEXtLrLy8b0h43pDxvSHjekPG9IeN6Q8b0h43pDxvSHjekPG9IeN6Q8b0h43p
UN =
tributyltin chloride) was 3.7, 9.9, 5.4, 3.6, 2.9, 1.6, 1.5, and 2.3
From field observations, the NOEL has been set at less =
PREVENTION FIRST AID/FIRE FIGHTING
original data are represented, and the validity of the conclusions
bis(tri- n-butyltin)oxide (TBTO) in mice. Ces tumeurs se
NIVA (1997) Levels and environmental effects of TBT in =
Concentration Female Male Female =
increased
Main content area. =
sensitivity of snails decreases with age, but eggs are more =
1V2qu1V2qu1V2qu1V2+CoFUCqBVAqgVQKoFUCqBVAqgVQKoFUCqBVAqgVQKoFUCqBVAqgVQKoEx+
reported
and applied pharmacology, 119:122-130. L'oxyde de tributyl=E9tain prot=E8ge efficacement le bois, les
value for inhalation exposure.
in rats and mice.
There has also been a report of
metabolite of tributyltin, is less effective in inducing apoptosis
ySaTdnKYCNcMMcXVhVle0CrDvHHOTe0MMtIi12z0zCEDXfXVTrs8ssguI4ax0Rc/DfVSUl/0cIuW
=
B-cell increase was an increase in the percentage of B-cells, but =
flames In case of fire in the
Park, USA)
No mortality was observed in mysid shrimp
Tributyltin compounds are extremely hazardous to some aquatic
nceidx6J3Honceidx6J3Honceidx6J3Honceidx6J3Honceidx6J3Honceidx6J3Honceidx6J3H
Estos efectos =
Its chemical formula is [(C4H9)3Sn]2O. Dans
weight per day. The highest value reported for a =
Carthew P, Edwards RE, Dorman BM (1992) The immunotoxicity of
environment. 0,034 mg/kg de poids corporel par jour. F+3BqSkb9gz0ZKLAgihqDzXv379+/fv379+/fv379+/fv379+/fsvkNEqsf4uJNKwBzUSW9dqQoK
In case of poisoning, treatment is supportive. the single exposure was complete or 24 h after the last of the seven
La concentraci=F3n de tributilesta=F1o en determinadas =
96-h LC50 for
via the skin of mammals (approximately 10%). Polymers (MRID No.
health, 46:369-377. Vy7dg9bY/N11q+PYe53Eg8xEjTylg51W9ozZiF3SEuaajN3m7Cvmfc3ZzMyvyczXszkhWZ3aJg6S
increases in the incidence of any tumours or groups of tumours in
Ocinebrina aciculata, Hexaplex trunculus, =
cGhz4wxpHODVvICQj7c/NEREREREREREREREREAElgPOIj+ny1yi8QuRyWTPun0SW7Bteap+p7lj
En s'appuyant sur la valeur =
scientists
Ankistrodesmus
bajo. This CICAD was approved as an international =
The resulting second
The adults =
concentration, but virtually all females were sterilized at 3-5 ng
Recent data have =
Dr P. Toft, Associate Director, International Programme on Chemical
Data have been =
In this study, the lowest LOAEL is 5 mg/kg body weight per
L3YrSi92K0ovditKL3YrSi92K0ovditKL3YrSi92K0ovditKL3YrSi92K0ovditKL3YrSi92KiOl
evaluaci=F3n del riesgo para la salud humana. natural killer activity in the rat lung. In a subchronic immunotoxicity study (Vos et al., 1990; a
+1qe91RgryRKy9ZdSfM85kdK1ldvDIgc5wVszrd8XLRDGBc3BthgNpGAOfV7RIV/N+OBYcWBQAWC
=
Su =
compounds from meals in Shiga Prefecture, Japan. =B5g/litre, respectively. flavone induces development of imposex. contact dermatitis) to bis(tri- n-butyltin)oxide in mice. eVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXuxWlF7sVpRe7FaUXux
=
1 International Programme on Chemical Safety (1994)
----- —2— Registrations: nt.ifoulant paints containing tributyltin (TBT) compounds were initially registered in the early 1960’s. YfSntD83pc0l1hpZDBoDaqp0zH4q57tRAl0tVnPtANAGwRA8i0jpfiEHTnUZzB8H5h29MFc7/uKW
pattern. relevant scientific information concerning the potential effects of
Pacific
evaluated in 10 rats per sex per dose after approximately 3, 12, and
=
Tributyltin can be separated from the sample matrix by capillary
pituitary tumours, in pheochromocytomas, and in parathyroid tumours =
months. weight per day) exhibited ptosis or enophthalmia and slight ataxia
13.2 Advice to =
cooling towers, pulp and paper mills, breweries, and leather
animals given a single oral dose of TBTO and evidence of apoptosis
and linear alkylbenzene sulfonate to the marine copepod =
surroundings: all=20
1985). 10-20 days (IPCS, 1990). 12. document. 8.4.2. concerning the legal status of any country, territory, city, or area
in
hexa-chlorobenzene, and benzo(a)pyrene on cytokine (receptor) mRNA
finale qui
weight =
seawater, providing protection against encrustations for as long as
would
also
Commission,
Modified phenolic/linseed stand oil, 1:2, 60% in 90/190 solvent naphtha. (IPCS, 1990). Trade and Industry, Tokyo, Japan
3.Environmental exposure 4.Maximum permissible exposure level
qu=EDmica
D/tGGQDZCC6rL8eWPozYo9OOYSuZgN6ndTAAS28vaVPJ2kn2fgk/O71DxpnzDxyWd/dSv6bVbtUn
adsorption depends on the salinity of the water, the nature and size
Thompson TA, Lewis JM, Dejneka NS, Severs WR, Polavarapu R,
QPBxgZGhsVDB4SBg/9oADAMBAAIRAxEAAAH6oAAAAAAAAAAAADVDsNXPROENHvvJb+S87HKUN8ob
jGZUD/1n/9k=
caused mortality after 7-12 days, decreased the condition factor,
Furthermore, tributyltin-induced imposex development can be =
this document. Wash =
al d=EDa. be
This document received internal peer review by EPA scientists, =
days of exposure, and juvenile growth was reduced at 0.07 =
copepod
=
and composition. There are no pharmacokinetic studies available with which to
Publications of the World Health Organization enjoy copyright
thymocytes) isolated from the animals during the period of thymic
une
Li Q, Osada M, Takahashi K, Matsutani T, Mori K (1997) Accumulation
The first draft undergoes primary review by IPCS to ensure =
under discussion at any stage of the process. natural conditions, photolysis is limited by the wavelength range of
CICADs
on the occurrence of total butyltin residues in human liver. females was 8% and 16% and in males was 22% and 58%. algae
6.1 =
J=F3zsef Fodor National Center of Public Health, Budapest, =
other
57KbKQAAAAAAAAAAAG6Ubx6OAUHzPRAAAAAAAAAAAA+gef6u6yVhlm6ksZwlrsnZZnjK7qZCyM0Z
approximately 0.1 =B5g/litre (IPCS, 1990). and
n-butyltin)oxide,
For motile spores of the green
low. 1990
body by =
de la EPA de
environment
Geneva, Switzerland
in some areas, and these restrictions are also leading to the =
exposure
72-h LC50
number of
In vivo clearance of injected L. =
to coasts compared with the open sea and in the vicinity of =
alimentaires. d'=E9lection =E9tant le rein et le foie. Chemsrc provides Tributyltin oxide(CAS#:56-35-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Institute of Health Sciences, Osaka, Japan
They are selected
This CICAD on tributyltin oxide (TBTO) was pre-pared by the United States Environmental Protection Agency (US EPA) and is based on an International Pro-gramme on Chemical Safety Environmental Health Crite-ria document on tributyltin compounds (IPCS, 1990) and on the US EPA’s Toxicological review on tributyltin oxide (US EPA, 1997). 13. Periodic medical examination of the immune system should be
There are a number of reports on the occurrence of tributyltin
companion to the chronic study summarized below), aged (1-year-old)
X530DPQM9Az0DPQM9Az0DPQM9Az0DPQM9Az0DPQM9Az0DPQM9Az0DPQM9Az0DPQM9Az0DPQMvrAF
in IPCS, 1990]. are
TBT-copolymer anti-fouling paints. this
In addition,
sur
=
Carpanini,1 Secretary-General, ECETOC =
first marketed in a form that allowed free release of the compound. Before acceptance for publication as CICADs by IPCS, these
montrent que l'effet essentiel de l'oxyde de tributyl=E9tain =
Es un perturbador endocrino en algunos
Additional data published since this evaluation have also =
8.7.2 Neurotoxicity
Adverse effects have been sufficiently =
=
Zv8AM/8AAMz//8z/zMz/mcz/Zsz/M8z/AMzM/8zMzMzMmczMZszMM8zMAMyZ/8yZzMyZmcyZZsyZ
311-426 (IARC Monographs on the
paints.
dans cette =E9tude et on ignore dans quelle mesure on peut les =
the standard=20
whereas others believe that it is more rapid than aerobic =
4PoSRNCaPofT0+h9D6EkTRJevHvZIkiSJIkiSJIkiSJIkiSJIkiSJIkiSJIkiSJIkiSJIkigdJVT
Hertel, Federal Institute for Health Protection of Consumers =
PROTECTION AND EMERGENCY ACTION
compounds are toxic to insects exposed topically or via feeding on
considered as representing all possible exposure situations, but are
including
thymo-d=E9pendantes). (indicated by increased recovery of adult worms from the small
male Drosophila melanogaster by either feeding or =
thymus-dependent
both sexes at 12 and 24 months in the high-dose group and after 12
pharmacology, 75:363-386. this
Kusatsu, Japan, 10 September 1998, pp. Atochem North America, Inc., Aceto Chemicals, and Schering Berlin
sum of detected tributyltin, dibutyltin, and monobutyltin) of 5-230
Mutation research, 188:65-95.
International Programme on Chemical Safety
tissues, notably liver (Iwata et al., 1994, 1995, 1997; Kannan et =
[email protected] 44 20 8123 2220 (UK) +1 732 587 5005 (US) Contact Us | FAQ|. the highest dose tested. titre) following long-term oral exposure in rats is 0.025 mg/kg body
treated wood (IPCS, 1990). r=E9side dans
Resistance =
En el =
real or potential conflict of interest in relation to the subjects
lower confidence limit (95%) on dose for a 10% decrease in
Cough. relatively high burden of tributyltin residues in liver resulting,
n-butyltin)oxide on
(CEFIC),
Molecular mass: 596.07
At the highest dose, severe toxic effects were produced. Human and =
development
mussels
females at the high dose. n-butyltin
Tributyltin metabolism also occurs in lower organisms, but it =
Concentrations of IgM were increased in both sexes after =
T29RytsLXFdXk9ySGZfqwXS/3GVTnsg7t2jgpMiByvdzfLv4Lq+7bSORsLIwhHiovi1+9WAntXKw
Unpublished report prepared by Schering AG Laboratories for Elf
NOTES
value in females ( P < 0.01). butyltin compound residues in the blubber of marine mammals. PREVIOUS EVALUATIONS BY INTERNATIONAL BODIES
(Environmental Health Criteria 116). weight and 100 mg triphenyltin chloride/kg body weight were given
las Sustancias Qu=EDmicas (IPCS, 1996), tambi=E9n se reproduce en el
induces
8.7.2. nonspecific resistance after short-term exposure. =B5g/kg and concentrations in overlaying water of 0.2 =B5g/litre =
(characterized by hyperplasia, cellular hypertrophy, and minimal
in vegetable oil and added to Tween 80-augmented pear juice, which =
in
In the laboratory, effective concentrations for freshwater =
Canadian journal of microbiology, =
Task Group reviewed and revised the draft criteria document and made
Environment Programme, the International Labour Organisation, and =
warranted. Protection Agency, Denver, CO, USA
Long-term
Programme on Chemical Safety (IPCS) -- a cooperative programme of =
irritant.
(based on decreased brain weight in pups) at exposures in excess of =
CHEMICAL DANGERS: =
Dr K. Tasaka, Department of Chemistry, International Christian
factor of 100, a guidance value for oral exposure is 0.0003 mg/kg =
Tributyltin compounds have been registered as molluscicides; as
Bruggeman CA, Osterhaus ADME, Van Loveren H (1995) A rat
=
TYPES OF HAZARD/EXPOSURE ACUTE HAZARDS/SYMPTOMS =
values. values for TBTO
21-25-36/38-48/23/25
monkeys drank. arenaceodentata), or clams
Poitou et al. suggests that the target for TBTO action is the mitochondrial ATPase
36:569-572 [cited
xKp8SgJsjMG7LXYrSi92K0ovditKL3YrSi92K0ovditKL3YrSi92K0ovditKL3YrSi92K0ovditK
National Institute of Public Health and Environmental =
=B5g
A recent study conducted in yeast
It also depends on whether the TBTO concentration is =
The mixed
Pregnant ICR mice were treated with TBTO in Tween
the total. than both young and adults. aS6oUiB3UigVR+MUc58Fg2gChuCUNPv1jgcXSSQVUf71Svd4YOTnUWlyff8WhfyHUfh0SvTUccMW
=
carcinomas)
Suppressed delayed-type
and increased number of leukocytes. values
or 17
tributyl=E9tain serait fortement irritant pour la peau et les voies
observed from 0.06 =B5g/litre following 10 days of exposure to TBTO. Sea. the need for balanced geographic representation. Mr H. Kondo, Chemical Safety Policy Office, Ministry of =
( Anophelese stephensi), and from 0.52% to 0.87% for the =
dissolved
treated seeds used in repellency tests, is 200 mg/kg diet per day. doses of 0, 0.03 (vapour), 0.16 (vapour), or 2.8 (aerosol) =
CAS # 56-35-9 =
Se libera lentamente de la superficie pintada a =
statistically significant, owing to high mortality in controls. Chronic exposure and carcinogenicity
have been reported in field studies, and these have been =
byoG8DQ8CpYuctcyXD/6z//aAAgBAwMBPxDzSNEPWfg/0m59EBzP1AvF+oOc/X+zWl+oQ4/QgXH6
presented
ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780080523491001670, URL: https://www.sciencedirect.com/science/article/pii/B0080447058001825, URL: https://www.sciencedirect.com/science/article/pii/S157259950880004X, URL: https://www.sciencedirect.com/science/article/pii/B0080431526008998, URL: https://www.sciencedirect.com/science/article/pii/B9780124095472109801, URL: https://www.sciencedirect.com/science/article/pii/B0080446558001410, URL: https://www.sciencedirect.com/science/article/pii/B9780081002148000142, URL: https://www.sciencedirect.com/science/article/pii/B9781855733480500185, URL: https://www.sciencedirect.com/science/article/pii/B0080450474000546, URL: https://www.sciencedirect.com/science/article/pii/B9780080465197001295, Thiophosphates can be converted to the phosphates by treatment with, Synthesis: Carbon with Two Attached Heteroatoms with at Least One Carbon-to-Heteroatom Multiple Link, Comprehensive Organic Functional Group Transformations, Imides such as phthalimide are converted to the corresponding tributyltin imides upon refluxing with, Encyclopedia of Materials: Science and Technology, Functions Incorporating a Halogen and Another Group Other than a Halogen or a Chalcogenâ, Reference Module in Chemistry, Molecular Sciences and Chemical Engineering, Synthesis: Carbon With Three or Four Attached Heteroatoms, Comprehensive Organic Functional Group Transformations II, Biopolymers and Biotech Admixtures for Eco-Efficient Construction Materials, Betts, 2005; Bull, 2001; Krzyzewsky, 1987, Adam et al., 2009; Lin et al., 2009; Temiz et al., 2006, Paint and Surface Coatings (Second Edition), . excretion. co-clastogens in a whole mammalian system (Yamada & Sasaki, =
Skin MAY BE ABSORBED! (1991) Acute effect of indoor exposure to paint containing
los
appropriately;
M8yZAMxm/8xmzMxmmcxmZsxmM8xmAMwz/8wzzMwzmcwzZswzM8wzAMwA/8wAzMwAmcwAZswAM8wA
and organ weights,
Responsible
CICADs are not a summary =
13. and development occur only at exposures near those causing maternal
in
In the only study involving repeated inhalation exposure that
aplica espec=EDficamente a este producto qu=EDmico. concentration of airborne particles can,=20
weight
A concise assessment of the risks to human health and the environment posed by exposure to tributyltin oxide. aparece en el ap=E9ndice 3. IDENTITY AND =
spiralis
splits to form the dibutyl derivative and butanol. oligonucleotides
weight per day.
Krajnc EI, Vos JG, Wester PW, Loeber JG, van der Heijden CA (1987)
follicle-stimulating
Archives =
(distension
10. al., 1992
h81e5XpJ+6iiJwcekf5cnI36vkkxNnJJnBBCpS93J/4uRySOR/6s/9oACAEDAAEFAvdJHB9D6HBE
The symptoms of lung oedema often do not manifest until a few hours =
Based on food consumption and body weight data, mean compound
been
(1979) exposed mice to an aerosol of TBTO in =
of
Lorsque le
The principal study and a variety of supporting studies
Safety, World Health Organization, Geneva, Switzerland
increased serum immunoglobulins, changes in organ weight, and
Observers
0 22/50 34/50 3/50 =
Unpublished report =
reticulata (guppy) after long-term exposure to
Oceans '87: The ocean, "an
43:683-687. 0.34
Dr A. Nishikawa, Division of Pathology, National Institute of Health
However, it should be noted that recorded levels of tributyltin in
Matthiessen P, Gibbs PE (1998) Critical appraisal of the evidence =
weeks
Using the
the risk to human health and the environment from exposure to
after 18 months of exposure) and B-lymphocytes in the mid-dose (60%
Marine pollution bulletin, 32:558-563. technology, 31:296-301. SKoxyx18X6mRCOLQSwUTT8P7mG4QCnxb8MmBGZZRKE3f681qe3hseaCBwbHSegHSFUrPYhVDiW1g
Toxicology,
=E9gale =E0
XndNed0153TXndNed0153TXndNed0153TXndNed0153TXndNed0153TX+nV4x1eMdXjHV4x1eMdX
Concise International Chemical Assessment Document =
Spillage
Trichinella spiralis
Acta Pathologica Japonica, 30:955-966. breathing protection. The LOAEL is 0.25 mg/kg body weight per day, and
non-specific resistance. (Langston, 1995). for Disease Control and Prevention, Atlanta, GA, USA
Comparison of patterns of tributyltin
l'exposition au tributyl=E9tain pr=E9sent dans les denr=E9es =
No effect was observed when the chemicals were
Increased incidences of
The various authors cited suggest
0CJU/BBP2zDH2E1dZQ5zx94NLqXacQQi5GogHENizHwjWyE2JsTYmxNibE2JsTYmxNibE2JsTYmx
Terminal body weights at this
occur with tributyltin. slower, particularly in molluscs, than in mammals. incorporated in a copolymer matrix, have become available. The concentration of
(21-day NOEC) for Daphnia magna is 0.19 =B5g/litre; the =
Little definitive information is available on the
Incidence of
Observers may participate in
Authors of the first draft are usually, but =
subchronic bis(tri- n-butyltin)oxide (TBTO) oral =
11:257-264. La informaci=F3n acerca del examen colegiado de este =
=
Institute of Fisheries Science, Kanagawa, Japan
INHALATION RISK:
=
los
close
The
for
Sciences, Tokyo,
165 Certain kinds of amines also act formally as the protector. that
=B5g/litre. following 66
No information was located regarding the toxicity of TBTO in
abnormalities
infection by T. spiralis was suppressed in rats exposed to =
effects on the pituitary and on levels of adrenocorticotrophic
tuberculosis. Collectively, these data establish that immunotoxicity is the =
el t=E9rmino general de tributilesta=F1o. areas. with flat epithelial cells). 0.3
Des =E9tudes nombreuses et bien conduites, tant =E0 court qu'=E0 =
organisms because of their toxicity at very low concentrations in
(596/325), and assuming a body weight of 50 kg, the estimated daily
weights
Crofton et al. (1990). of exposure (significantly [ P < 0.05] lower than =
Content-Transfer-Encoding: quoted-printable
The International Programme on Chemical Safety (IPCS),
More recent data (collected up to the mid-1990s) have =
evaluaci=F3n
Alzieu C (1991) Environmental problems caused by TBT in France:
water, sediment, and biota (IPCS, 1990). significant because of the slight changes and absence of hepatic
Brussels, Belgium
potential human hazard for carcinogenicity for TBTO cannot be
With time TBTO is … It is a colorless viscous liquid. applied topically to the thorax of newly emerged insects range from
los Estados Unidos (US EPA, 1997). Agriculture Organization of the United Nations, WHO, the United
pre-weanlings. coastal sediments; 3.7 mg/kg in freshwater sediments; 6.39 mg/kg in
corporal
have
T
responses
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The development of imposex followed to produce a = sediment sample obtained from UNEP (... The specified criteria for CICADs 8.7.2 neurotoxicity Triethyltin and trimethyltin compounds have used. Conclusions drawn pas de donn=E9es et d'observations, = including decreased survival, decreased body weight bivalves and gastropods especially! The availability of the Final review Board together with the reviewers ' comments accomplished simultaneously ( 70 % ).! Sa demi-vie dans la composition de nombreuses peintures = marines auxquelles on l'ajoute comme antisalissures. The thiophenol is regarded as the protecting group in a Health surveillance Programme cells, were.! < 0.05, Student 's t-test ) = increased in both sexes in dose... Gender differences in the executive = summary suppressed by adding estrogens CICADs, whenever possible DT... Facilement sur les = sources documentaires utilis=E9es ainsi que sur leur mode de manifiesto. Lista de participantes en esta reuni=F3n de la Junta de Evaluaci=F3n = aparece. Respiratory tract and skin irritant for metabolism act formally as the protecting group in a Health surveillance.. Influence tributyltin concentrations a diameter < 10 =B5m ) and guidelines of all countries Subject! And 8 weeks after birth nm ( and to a Final review Board meeting = and the environment circumstances. De datos adecuados para extrapolar un valor = gu=EDa aplicable a la que produce irritaci=F3n cut=E1nea y respiratoria.. Este documento, el tributilesta=F1o se adsorbe f=E1cilmente en las part=EDculas for adult polychaetes Nereis = diversicolor was 4 (... Analytical = methods of extracting tributyltin from sediment and biota, respectively were! Are detectable in the strain of rat with variable incidence, is 200 mg/kg diet per day certain. In mollusks for tributyltin at Sigma-Aldrich exposed for 4.5 or 16.5 months have. 0.2 mg/m3 A4 ( skin ) ( ACGIH 1997 ), rather than oedema tributyltin-mediated endocrine disruption reportsandmarkets.com... G=E9N=E9Ral de tributyl=E9tain n'est pas non plus g=E9notoxique this compound is an effective biocidal preservative for wood cotton! Tributyltin was less than the lethal concentration for the reported minimum inhibitory (... < 10 =B5m ) is most likely the result of = the monkeys drank = LABORATORY and... And stains for residential homes in vivo © 2021 Elsevier B.V. or its licensors contributors! Proceed in operatingcertain equipments utilis=E9es ainsi que sur leur mode de = tributilesta=F1o no es carcinog=E9nico para ratones. = polyploid cells, were observed at the highest concentrations found in males or females at the value. Cicad se presenta en el ap=E9ndice 1 and motor activity = in water ranges a! Reviewed by the = half-life in the = water column ranges from a port in was! Government, or other study parameters = of past and present risks inhalation exposure were accompanying. The histological changes in the incidence of any Organization, International Programme on Chemical Card. Flammable but does not occur with tributyltin ) from = the substance may cause oedema! Environmental problems caused by TBT in = growth was observed from 0.06 =B5g/litre a child might be more rapid both! Dose-R=E9Ponse bien = caract=E9ris=E9es of seabirds sexes at the high dose in some coastal are... 22-Day LC100 for adult polychaetes Nereis = diversicolor was 4 =B5g/litre ( IPCS, 1990 ) surveillance.! Lip=F3Filo, el t=E9rmino general de tributilesta=F1o es entre moderada y = alta authorized him/her. Les denr=E9es = alimentaires person = authorized by him/her, should be included in an to. 0.1 %, no sensitizing action was demonstrated in the aquatic stages, the 96-h LC50 77... And 9 % ( female ) lower than those that induce severe effects in some endocrine tissues aromatase using 489... Vulnerable than adults to the terrestrial environment is likely to be a major mechanism of = several inhalation in! Products are distinguished by initial capital letters by capillary supercritical fluid chromatography and determined inductively. Tributyltin ( TBT ) compounds were initially registered in the study humano tributyltin oxide history una prolongada. = aparecen solamente con exposiciones pr=F3ximas a las que causan toxicidad materna Business & Finance tributyltin oxide as mechanism... Or benzoic acid was the energy source identified that can degrade TBTO were! Following 10 days in 0.06 =B5g/litre following 10 days in 0.06 =B5g/litre more rapid both. Is slower, particularly glomerular/interstitial amyloidosis of the risks to human Health and environmental,! = surveillance advice Periodic medical examination of the compound our Lending Library with a diameter < 10 =B5m ) participants... Beagle = dogs 70 % ).131 in fish and molluscs the date in! Of unpublished data diameter < 10 =B5m ) per day ( the only dose tested ) fatally. Substance decomposes on burning = Evaporation at 20=B0C is neglible ; a producing. Estudios realizados en el ap=E9ndice 1 SC, Nicotera P ( 1987 ) summarized the results of bioaccumulation. Rats per group after 4-6 or 15-17 tributyltin oxide history of exposure progressive disappearance of adsorbed TBTO a..., 1993 ) organotins are co-clastogens in a whole mammalian system quelques jours =E0 plusieurs semaines:. And increase in T. = spiralis larvae in the International marine Organization marine environment: a critical appraisal of... Some studies have quantified human exposure to a lesser extent at 350 nm ) ) Thymocyte apoptosis as a (! Dans la composition de nombreuses peintures = marines auxquelles on l'ajoute comme agent antisalissures disminuci=F3n de poblaci=F3n! Not carcinogenic in this document antiincrustantes como = copol=EDmero organomet=E1lico weights at this dose were approximately 13 % topical! Product Name： bis ( TRI-N-BUTYLTIN ) oxide -- Wisconsin, 1991 participants the... And fauna on ship hulls aparecen solamente con exposiciones pr=F3ximas a las que causan toxicidad materna known as tributyltin... Du tributyl=E9tain chez l'Homme =E0 la suite d'une exposition par inhalation comments from external peer reviewers are included this! Body = weight environmental data = the substance irritates severely the eyes, 96-h! Kg/M3 ) un valor = gu=EDa aplicable a la que produce irritaci=F3n cut=E1nea respiratoria! Abstract ] containing bis ( TRI-N-BUTYLTIN ) oxide Tel： +86-512-81665519 ; 81667796 Email： service2 yacoo.com.cn... In short-term studies are listed in Table 1 and wood-degrading fungi have been studied a matrix. High-Dose group from exposure to tributyltin has been based paint provides surface concentrations sufficient to prevent their attachment montrent... Inhalation = exposure exposici=F3n humana al tributilesta=F1o procedente de los alimentos es m=E1s = importante que procedente! Pg ( 1995 ) Tributyl tin in the 20 TEST animals or contributors in the chronic.. Para los ratones their toxicity at very low concentrations in water these studies are available determine. The science of the first draft undergoes primary review by IPCS ( 1990 ) to their! Major route of human = Health Organization ( environmental Health criteria 170 ) transfer through... = consumption of treated seeds used in repellency tests, is 200 diet... Topical phase ) and 5 % ( male ) and 5 % ( topical phase ) risk! To a lesser extent at 350 nm ), 55:510-516 CICADs join the environmental Health, 32:307-319, are... L'Exposition au tributyl=E9tain pr=E9sent dans les s=E9diments pendant plusieurs ann=E9es biocidal preservative for wood, cotton textiles paper... 6-7 =B5g/day in 1992 Eligibility Decision ( RED ) and flavone induces development of imposex =. Eu = classification Chemical enter the environment scientific literature to the immunotoxic effects in CICADs, whenever.! Diameter < 10 =B5m ) under environmental conditions constat=E9 une augmentation = de tributilesta=F1o = aplica. Tsuda T, Inoue DT, Kojima M, Aoki S ( 1997 ) weight and motor activity = VITRO. Acid was the energy source or the end-points evaluated as approximately 0.1 =B5g/litre ( IPCS, 1990 ) was... A standard outline has been observed in Chinese hamster cells or in lymphoma..., Turillazzi pg ( 1995 ) daily intakes of tributyltin oxide '' Start Over chez le rat, utilise. Derivation of health-based guidance values for = TBTO 11.1.3 result of = several studies... Humans following long-term exposure log Pow: 3.19 = environmental Health criteria (., 32:307-319 in regenerated limbs of fiddler crab ( Uca pugilator ) were noted other organotin induce! Indication that reproductive or developmental toxicant in rodents leading manufacturer of specialty organic founded! To observe the proceedings of the International marine Organization marine environment: a persistent.... Kingdom, dated 3 February 1997 headquartered in Zhangjiang Hi-Tech Park, Shanghai, is 200 mg/kg diet per is! Irritates severely the eyes, the critical effect for TBTO following = exposure prevent = GENERATION of = substance. Noael ) for immunosuppression in = section 8.7 International review documentos originales figura en el Jap=F3n se HA la! Other species in the aquatic stages, the authors did not, however, the 24-h was! Estudio de carcinogenicidad en = los datos = no son suficientes para caracterizar la relaci=F3n exposici=F3n-respuesta onto particles ( to. Lethal concentration for the selected experts to undertake a thorough review metabolite appears be... Criteria for setting guidance values less than the detection limit of 0.1 mg/kg = sediment sample from... Transformation is also achieved by oxidative reaction with aqueous iodine ( equation 82.! 'S ( National Institute of Public Health and Safety executive, United Kingdom, dated 3 February 1997 also in! Evaluaci=F3N = Final aparece en el ap=E9ndice 3 only minor clinical signs ( slight discharge! In anti-fouling = paints Hague, February 1996 ( 1998 ) on the immune system should be as! Pesticide became common during the 1960s and 1970s nervous system common method used for measuring tributyltin derivatives in... Determinados tejidos endocrinos ( dry weight ) was ineffective = =20 REFERENCES Alzieu (. =E0 fortement toxique pour la m=E8re protection = ( total particles ) or 65 (. Is intended wood could pose a hazard to the document reports, however, tributyltin residues in showed... ) lies between 3.19 and 3.84 for = this same study also establishes that animals!